An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles

作者：Simovic Spomenka; Hui He; Song Yunmei; Davey Andrew K; Rades Thomas; Prestidge Clive A^*

来源：Journal of Controlled Release, 2010, 143(3): 367-373.

DOI：10.1016/j.jconrel.2010.01.008

• Poorly soluble drugs
• Indomethacin
• Lipid-based oral delivery
• In-vitro dissolution
• In-vivo pharmacokinetics

We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (similar to 1-5 mu m) or phase coacervation (20-50 mu m) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p < 0.05) in comparison to aqueous suspensions and o/w submicron emulsions of indomethacin. It is postulated that the SLH microcapsules improve oral absorption via complete solubilisation of drug-lipid electrostatic complexes during enzymatic lipolysis in the GI track.

• 出版日期2010-5-10