Angiodysplasia in embryo lacking protein arginine methyltransferase 1 in vascular endothelial cells

作者：Ishimaru Tomohiro; Ishida Junji; Kim Jun Dal; Mizukami Hayase; Hara Kanako; Hashimoto Misuzu; Yagami Ken ichi; Sugiyama Fumihiro; Fukamizu Akiyoshi^*

来源：Journal of Biochemistry, 2017, 161(3): 255-258.

DOI：10.1093/jb/mvw095

• angiodysplasia
• conditional knockout
• endothellial cells
• in vivo imaging
• protein arginine methyltransferase 1

Protein arginine methyltransferase 1 (PRMT1) is involved in multiple cellular functions including proliferation and differentiation. Although PRMT1 is expressed in vascular endothelial cells (ECs), which are responsible for angiogenesis during embryonic development, its role has remained elusive. In this study, we generated endothelial-specific prmt1-knockout (Prmt1-ECKO) mice, and found that they died before embryonic day 15. The superficial temporal arteries in these embryos were poorly perfused with blood, and whole-mount 3D imaging revealed dilated and segmentalized luminal structures in Prmt1-ECKO fetuses in comparison with those of controls. Our findings provide evidence that PRMT1 is important for embryonic vascular formation.

• 出版日期2017-3