Na+/K+-ATPase inhibition upregulates NMDA-evoked currents in rat hippocampal CA1 pyramidal neurons

作者：Zhang, Linan; Guo, Fang; Su, Suwen; Guo, Huicai; Xiong, Chen; Yin, Jian; Li, Wenya; Wang, Yongli^*

来源：Fundamental & Clinical Pharmacology, 2012, 26(4): 503-512.

DOI：10.1111/j.1472-8206.2011.00947.x

• hippocampus
• learning and memory
• mitogen-activated protein kinases
• Na
• K plus -ATPase
• N-methyl-d-aspartate
• Src tyrosine kinase

Na+/K+-ATPase and N-methyl-d-aspartate (NMDA) receptor in hippocampus play very important roles in the regulation of learning and memory. Here, we showed that dihydroouabain (DHO, 10-510-3 m), a Na+/K+-ATPase inhibitor, significantly potentiated NMDA current in rat hippocampal CA1 pyramidal neurons, which was blocked by PP2 (the selective Src tyrosine kinase inhibitor) and PD-98059 [the selective inhibitor of the mitogen-activated protein kinases (MAPK) cascade]. These findings reported here uncover that Src mediates the cross-talk between Na+/K+-ATPase and NMDA receptor to transduce the signals from Na+/K+-ATPase to the MAPK cascade and provide new insights into therapeutic target for deeper understanding of the nature of cognitive disorder.

• 出版日期2012-8
• 单位河北科技大学; 河北医科大学