A further study of a possible locus for schizophrenia on the X chromosome

作者：Wei, Jun^*; Hemmings, Gwynneth P.

来源：Biochemical and Biophysical Research Communications, 2006, 344(4): 1241-1245.

DOI：10.1016/j.bbrc.2006.04.018

• CACNA1F gene
• SYP gene
• FACL4 gene
• X chromosome
• schizophrenia

Several studies suggest that the X chromosome may contain a gene for schizophrenia. In the present study, we recruited 142 male schizophrenic patients and their biological mothers from all parts of the United Kingdom to detect a genetic association for the SYP/CACNA1F locus in the Xp11 region and the FACL4 locus in the Xq22.3-Xq23 region. The haplotype-based haplotype relative risk (HHRR) analysis showed allelic association for rs2071316 (chi(2) = 6.85, P = 0.009) and rs5905724 (chi(2) = 5.3, P = 0.02 1) at the CACNA1F locus, but not for rs5943414 and rs1324805 at the FACL4 locus and rs3817678 at the SYP locus. The haplotype analysis showed a 2 weak association for the rs3817678-rs2071316-rs5905724 haplotypes (chi(2) = 12.19, df = 4, P = 0.016) but did not show such an association for the rs5943414-rs1324805 baplotypes (chi(2) = 3.96, df = 2, P = 0.138). Because the linkage disequilibrium signal was detected only at the CACNA1F locus, this gene should perhaps be considered as being a candidate for schizophrenia although further work is needed to draw firm conclusions.

• 出版日期2006-6-16