Diazonamide studies. A direct synthesis of the indole bis-oxazole fragment from tri- and tetra-peptides using biomimetic oxidative cyclizations

作者：Sperry Jonathan; Moody Christopher J^*

来源：Tetrahedron, 2010, 66(33): 6483-6495.

DOI：10.1016/j.tet.2010.03.012

• Peptide
• Heterocycle
• Natural product
• Oxidation

The oxidation of several readily prepared tryptophan containing tri- and tetrapeptides with DDQ results in a biomimetic cyclization and direct formation of the indole bis-oxazole fragment of diazonamide A, establishing that such a transformation is a viable route when considering the biosynthetic formation of the heterocyclic core of the natural product.

• 出版日期2010-8-14