A PHARMACO-TOXICOLOGICAL EVALUATION OF BETULINIC ACID MIXED WITH HYDROXIPROPILGAMMA CYCLODEXTRIN ON IN VITRO AND IN VIVO MODELS

作者：Dehelean Cristina A^*; Soica Codruta; Peev Camelia; Ciurlea Sorina; Feflea Stefana; Kasa Peter Jr

来源：Farmacia, 2011, 59(1): 51-59.

• betulinic acid
• skin pathology
• cyclodextrin
• cancer

Betulinic acid (3 beta, hydroxy-lup-20(29)-en-28-oic acid, BA) is a pentacyclic triterpene previously tested on several cell lines of neuroectodermal origin and on some in vivo tumor models, such as the melanoma model. The aim of the present work was to test its activity by increasing its water soluble fraction with gamma type cyclodextrins (hydroxipropilgamma cyclodextrin). The study consisted in a preliminary in vitro evaluation on A431 and MCF-7 cell lines and in vivo tests on fertilized eggs. The dissolution capacity in presence of cyclodextrin was analysed by the phase diagram. The main conclusion was that betulinic acid possessed an important antiangiogenic activity and a significant cytotoxicity, especially on the A431 cell line.

• 出版日期2011-2