Activation of 1,1-difluoro-1-alkenes with a transition-metal complex: Palladium(II)-catalyzed Friedel-Crafts-type cyclization of 4,4-(difluorohomoallyl)arenes

作者：Yokota Misaki^*; Fujita Daishi; Ichikawa Junji

来源：Organic Letters, 2007, 9(22): 4639-4642.

DOI：10.1021/ol702279w

Cationic palladium(II) ([Pd(MeCN)(4)](BF4)(2)) provides the first transition-metal-catalyzed method for electrophilic activation of electron-deficient 1,1-difluoro-1-alkenes, which allows their Friedel-Crafts-type cyclization with an intramolecular aryl group via a Wacker-type process. By using BF3 center dot OEt2, the cyclization was effected by a catalytic amount of the palladium without its reoxidation.

• 出版日期2007-10-25