A novel PEG-haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer-drug conjugates in a non-prodrug fashion

作者：Heath Felicity; Newman Amy; Clementi Chiara; Pasut Gianfranco; Lin Hong; Stephens Gary J; Whalley Benjamin J; O**orn Helen M I; Greco Francesca

来源：Polymer Chemistry, 2016, 7(47): 7204-7210.

DOI：10.1039/c6py01418f

A PEG–haloperidol conjugate was synthesised, which retains binding to the dopamine D2 receptor, showing the possibility of using polymer-drug conjugates as drugs per se' rather than as prodrugs.

• 出版日期2016