科研之友
微信
新浪微博
Facebook
分享链接
摘要
An elevated preoperative aspartate aminotransferase (AST) to platelet ratio index (APRI) is reported to be a prognostic factor for patients with hepatocellular carcinoma (HCC) after treatment. However, delta APRI (Delta APRI), which represents the change from preoperative to postoperative APRI, has received little attention. The present study was designed to evaluate the prognostic value of Delta APRI in patients with small HCC after liver resection. @@@ A retrospective cohort study analyzing 244 patients with small HCC who had undergone liver resection was conducted. Medical data were retrieved from our prospectively maintained database. Patients were divided into 2 groups according to Delta APRI as follows: group A (Delta APRI >= 0.02) and group B (Delta APRI < 0.02). The association of demographic and clinical data, overall survival (OS), and recurrence-free survival (RFS) were statistically compared in the 2 groups, and a multivariate analysis was used to identify prognostic factors. @@@ The 1, 3, and 5-year OS of patients in group A were 94.2%, 79.5%, and 62.3%, respectively, and 95.1%, 87.9%, and 84.6%, respectively, for patients in group B (P= 0.001). The corresponding 1, 3, and 5-year RFS was 69.0%, 44.7 %, and 28.1%, and 77.4%, 57.0%, and 54.2% for patients in the 2 groups, respectively (P= 0.009). The results of a multivariate analysis indicated that DAPRI was an independent prognostic factor for both OS (P= 0.001, hazard ratio 3.115, 95% confidence interval 1.642-5.912) and RFS (P= 0.006, hazard ratio 1.689, 95% confidence interval 1.163-2.452). @@@ A positive Delta APRI after liver resection predicts decreased OS and RFS in patients with small HCC.
- 出版日期2016-7
- 单位四川大学
