Decreased expression of miR-32 is associated with the clinical outcome of non-small cell lung cancer patients

作者：Sun, Yu; Cong, Lele; Zhong, Xiaoming; Ma, Yushui; Luo, Ping; Liu, Miao; Yang, Huiqiong; Cong, Xianling; Fu, Da; Zhao, Qing^*; Liu, Xingdang^*

来源：International Journal of Clinical and Experimental Pathology, 2017, 10(5): 6021-6028.

• miR-32 expression
• non-small cell lung cancer
• clinical factors
• prognosis

To investigate the role of miR-32 expression in Chinese non-small cell lung cancer (NSCLC) patients, levels of miR-32 were analyzed using the data from GEO datasets. MiR-32 expression was lower in lung cancer patients than in normal controls. Then we explored the levels of miR-32 in tumor tissues and adjacent non-cancerous tissues of 65 NSCLC patients from the ArrayExpress Microarray database and 149 samples from our biopsies. Our results showed that there were no significantly differences between miR-32 expression and age, gender, lymph node metastasis, tumor differentiation, histology, TNM stage, visceral pleural invasion, vascular invasion, and tumor size. However, miR-32 expression was down-regulated in tumor tissues. Moreover, patients with low miR-32 expression had poorer overall survival and disease free survival, indicating that miR-32 expression might be an independent prognostic marker for NSCLC patients.

• 出版日期2017
• 单位吉林大学; 复旦大学