An Efficient Synthesis of Racemic Tolterodine

作者:Rao K Sudarshan; Rao K Nageswara; Muralikrishna P*; Jayashree A
来源:Asian Journal of Chemistry, 2014, 26(9): 2813-2814.
DOI:10.14233/ajchem.2014.15708

摘要

The efficient and cost effective of the synthesis of (+/-)-tolterodine (+), a precursor of (+)-(R)-tolterodine was efficiently performed from 6-methyl-4-chroman-2-one (2) via 4 steps in high yield. This process is suitable for large-scale commercial production by avoiding hazardous reagents and high pressure of hydrogen gas.

  • 出版日期2014-5