An Outbreak of Diarrhea in Mandera, Kenya, due to Escherichia coli Serogroup O-Nontypable Strain That Had a Coding Gene for Enteroaggregative E-coli Heat-Stable Enterotoxin 1

作者：Ochi Sadayuki; Shah Mohammad; Odoyo Erick; Bundi Martin; Miringu Gabriel; Guyo Sora; Wandera Ernest; Kathiiko Cyrus; Kariuki Samuel; Karama Mohamed; Tsuji Takao; Ichinose Yoshio^*

来源：The American Journal of Tropical Medicine and Hygiene, 2017, 96(2): 457-464.

DOI：10.4269/ajtmh.16-0310

In an outbreak of gastroenteritis in December 2009, in Mandera, Kenya, Escherichia coli O-nontypable (ONT) strain was isolated from stool specimens of patients (18/24, 75%). The E. coli ONT organisms could not be assigned to any of the recognized diarrheagenic groups of E. coli. However, they possessed the enteroaggregative E. coli heat-stable enterotoxin-1 gene. The cell-free culture filtrates of the E. coli ONT strain isolated from the outbreak cases induced considerable amount of fluid accumulation in suckling mouse intestine, indicating production of an enterotoxic factor(s). These results identify E. coli that did not have any diarrheagenic characteristics except astA as the etiological agent of the diarrheal outbreak in Mandera. It is however considered necessary to characterize the fluid accumulation factor(s) to determine whether any novel toxins were responsible for the fluid accumulation. Moreover, it is important to study dissemination of strains producing the enterotoxic factor(s) to assess their public health significance distribution in the environment.

• 出版日期2017