An investigation into the origin of the dramatically reduced reactivity of peptide-prolyl-thioesters in native chemical ligation

作者：Pollock Samuel B; Kent Stephen B H^*

来源：Chemical communications, 2011, 47(8): 2342-2344.

DOI：10.1039/c0cc04120c

The low reactivity of peptide-prolyl-thioesters in native chemical ligation is not due to steric effects at the beta-carbon, but rather to the presence of a carbonyl moiety on the nitrogen atom of the proline.

• 出版日期2011