Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition

作者：Stewart C Allison; Byers Lauren Averett^*

来源：Cancer Cell, 2015, 28(1): 4-6.

DOI：10.1016/j.ccell.2015.06.011

In this issue of Cancer Cell, Mohammad et al. describe LSD1, a histone demethylase, as a therapeutic target in SCLC with a unique epigenetic signature to predict drug sensitivity. Inhibition of LSD1 reduces cell proliferation and stem cell maintenance while promoting cell differentiation and reducing tumor growth in preclinical models.

• 出版日期2015-7-13