An efficient synthesis of enantiomerically enriched trifluoromethylated 1,2-diols and 1,2-amino alcohols with quaternary stereocenters by diastereoselective addition of TMSCF3 to chiral 2-acyl-1,3-perhydrobenzoxazines

作者：Pedrosa R^*; Sayalero S; Vicente M; Maestro A

来源：Journal of Organic Chemistry, 2006, 71(5): 2177-2180.

DOI：10.1021/jo052458v

TMSCF3 adds to chiral 2-acyl-1,3-perhydrobenzoxazines with total diastereoselectivity leading to quaternary trifluoromethyl alcohols. Further transformation of the addition products yields enantiomerically enriched trifluoromethylated 1,2-diols and 1,2-amino alcohols.

• 出版日期2006-3-3