科研之友
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摘要
BACKGROUND: To assess the efficacy and safety of individualised dose optimisation of irinotecan monotherapy as salvage treatment for advanced gastric cancer (AGC). %26lt;br%26gt;METHODS: A total of 43 patients were enrolled. Intravenous irinotecan (350 mgm(-2)) was administered every 3 weeks. The dose was increased (425 mgm(-2) and 500 mgm(-2)) or decreased (250 mgm(-2)) depending on patient tolerance. UGT1A1 genotypes were determined by direct sequencing of genomic DNA extracted from peripheral blood. %26lt;br%26gt;RESULTS: A total of 183 cycles of irinotecan were administered, with a median of four cycles per patient. The overall response rate was 9.3%, and the disease control rate was 62.8%. Median time to disease progression was 2.8 months, and median overall survival was 8.0 months. Grade 3-4 neutropenia was the most common toxicity (53.5%), and febrile neutropenia was the least common toxicity (4.6%). Compared with defective allele groups, UGT1A1 *11 was associated with a lower incidence of grade 3-4 neutropenia during the first cycle (P = 0.018). %26lt;br%26gt;CONCLUSION: Individualised irinotecan dose escalation based on patient tolerance was not associated with increased toxicity and shows modest activity as salvage chemotherapy for AGC. The role of UGT1A1 genotype in clinical toxicity requires further evaluation. British Journal of Cancer (2012) 106, 1591-1597. doi:10.1038/bjc.2012.143 www.bjcancer.
- 出版日期2012-5-8
