Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: Insights into nonfouling properties of zwitterionic materials

作者：Chen SF; Zheng J; Li LY; Jiang SY^*

来源：Journal of the American Chemical Society, 2005, 127(41): 14473-14478.

DOI：10.1021/ja054169u

In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMS) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.

• 出版日期2005-10-19