Utility of F-18-FDG PET/CT in the diagnosis and staging of extramammary Paget's disease

作者：Tian, Ying; Wu, Hu-Bing; Li, Dong-Li; Li, Hong-Sheng; Zhou, Wen-Lan; Wang, Quan-Shi^*

来源：Nuclear Medicine Communications, 2015, 36(9): 892-897.

DOI：10.1097/MNM.0000000000000340

• diagnosis
• extramammary Paget's disease
• fluorine-18
• fluorodeoxyglucose
• PET/CT
• staging

PurposeExtramammary Paget's disease (EMPD) is rare, and limited data have been reported on the utilization of fluorine-18 fluorodeoxyglucose PET/computed tomography (F-18-FDG PET/CT) in this disease. The aim of this study is to evaluate the role of F-18-FDG PET/CT in the diagnosis and staging of EMPD.Materials and methodsWhole-body F-18-FDG PET/CT images of 10 patients with newly diagnosed or recurrent EMPD were retrospectively analyzed. The lesion with increased F-18-FDG uptake was considered positive and was measured using the maximum standardized uptake value (SUVmax). The results of PET/CT were compared by conventional staging examinations.ResultsAll malignant lesions showed increased F-18-FDG uptake, except for some small lung metastases. Whole-body F-18-FDG PET/CT detected all primary lesions in four newly diagnosed patients and recurrences in the primary sites in two patients. Two thick lesions showed intense uptake of F-18-FDG (SUVmax: 14.9 and 7.5) whereas four thin lesions had only mild F-18-FDG uptake (mean SUVmax: 3.250.24). A false-positive result was found in one patient with suspected primary recurrence. F-18-FDG PET/CT also detected lymph node metastases in six patients, bone metastases in five patients, liver metastases in two patients, lung metastases in one patient, and an adrenal gland metastasis in one patient. Compared with conventional staging examinations, three of 10 patients were upstaged by PET/CT.Conclusion(18)F-FDG PET/CT diagnosis of primary lesions in EMPD is mainly dependent on the thickness of the lesions, whereas it is more sensitive for the diagnosis of metastases.

• 出版日期2015-9
• 单位南方医科大学