Acute response to oral calcium loading in pregnant and lactating women with a low calcium intake: a pilot study

作者：Schoenmakers I^*; Jarjou L M A; Goldberg G R; Tsoi K; Harnpanich D; Prentice A

来源：Osteoporosis International, 2013, 24(8): 2301-2308.

DOI：10.1007/s00198-013-2280-2

• Calcium
• Calciumexcretion
• Lactation
• Parathyroid hormone
• Phosphate
• Pregnancy

This pilot study in women from The Gambia with low habitual calcium intakes showed differences in calciotropic hormones between pregnant, lactating and non-pregnant, non-lactating women similar to those in Western women. The response to oral calcium loading indicates a high degree of calcium conservation independent of reproductive status.
In pregnancy and early lactation, parathyroid hormone (PTH) concentrations may be suppressed. Uncertainty exists about how calcium metabolism is regulated, particularly when calcium intake is low.
We investigated fasting markers of calcium metabolism and the acute calcemic and calciuric responses after an oral calcium load in 30 pregnant, lactating or non-pregnant, non-lactating (NPNL) Gambian women with low habitual calcium intakes. Women received 1 g elemental calcium (CaCO3) at 0 min. Blood was collected at -30 and 180 min. Urine was collected from -60 to 0, 0-120 and 120-240 min. Samples were analysed (blood: ionized calcium (iCa); plasma (p): total calcium (tCa), phosphate (P), creatinine (Cr), PTH, 1,25-dihydroxyvitamin D (1,25(OH)(2)D), osteocalcin (OC), beta C-terminal cross-linked telopeptide of type 1 collagen (beta CTX), cyclic adenosine monophosphate (cAMP); urine (u): Ca, P, Cr, cAMP).
Pre-loading, groups did not differ significantly in iCa, pP, uCa/Cr and uP/Cr. pOC concentrations were significantly lower and NcAMP and p1,25(OH)(2)D higher in pregnant women; pPTH and p beta CTX in lactating women were higher than in NPNL women. Post-loading, iCa, ptCa and uCa/Cr concentrations increased; pPTH, NcAMP, beta CTX and uP/Cr decreased in all groups, but the magnitude of change did not differ significantly between groups.
Differences between pregnant, lactating and NPNL Gambian women in pPTH, NcAMP and p1,25(OH)(2)D and bone markers were similar to Western women. However, the response to calcium loading indicates that there may be no differences in renal and intestinal calcium economy associated with reproductive status, potentially due to a high degree of calcium conservation associated with low intakes.

• 出版日期2013-8