A New Shield for a Cytokine Storm

作者:Iwasaki Akiko*; Medzhitov Ruslan
来源:Cell, 2011, 146(6): 861-862.
DOI:10.1016/j.cell.2011.08.027

摘要

Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endothelium at the center of this regulatory network.

  • 出版日期2011-9-16