Modulation of antibiotic activity by the hydroalcoholic extract from leaves of Caryocar coriaceum WITTM

作者：de Lacerda Neto Luis J; Ramos A G B; Kerntopf M R; Coutinho H D M^*; Quintans Junior L J; Almeida J R G S; Ribeiro Filho J; Menezes I R A

来源：Natural Product Research, 2018, 32(4): 477-480.

DOI：10.1080/14786419.2017.1312396

• Antibiotic
• antibiotic modifying activity
• synergism
• pequi

The aim of this study was to identify the presence of tannins, phenols and flavonoids on the hydroalcoholic extract of Caryocar coriaceum leaves (HECCL) and to determine the antioxidant and antibacterial activity of this extract. The extract was tested alone (1024-1g/mL) or associated (MIC/8) with several antibiotics in order to identify any antibacterial activity against multiresistant bacterial strains (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa). The existence of tannins, total phenols (901.31mg/g) and flavonoids (89.68mg/g) was confirmed in the HECCL. The presence of rutin and quercetin were confirmed by Thin-layer chromatography(TLC). Using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, the antioxidant activity of the extract (9g/mL) was determined. Moreover, the Minimum Inhibitory Concentration (MIC) value found for HECCL was 1024g/mL and the association between HECCL (MIC/8) with benzylpenicillin significantly changed its minimum inhibitory concentration from 2500 to 625g/mL against E. coli.
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• 出版日期2018