科研之友
微信
新浪微博
Facebook
分享链接
摘要
A novel multicomponent reaction of p-(trifluoromethyl)-p-quinolsilyl ethers, ketones, and nitriles was developed for the efficient synthesis of p-trifluoromethylated N-benzylamides. The key step of the reaction involves the formation of an unstable condensation precursor in situ generated form the condensation of p-(trifluoromethyl)-p-quinolsilyl ethers with ketones. This work provides a significant expansion to the Ritter-type reaction, and the reaction can proceed under mild reaction conditions and tolerate various nitriles including both aryl and aliphatic nitriles.
- 出版日期2018-10-19
- 单位东北师范大学
