Asymmetric Synthesis of Trifluoromethylated Amines and Their Derivatives

作者：Cheng, Gui-Lin^*; Wang, Hui; Lin, Xian-Fu; Wu, Qi^*

来源：Current Organic Synthesis, 2016, 13(4): 514-543.

DOI：10.2174/1570179413999160201151542

• Trifluoromethylated amines
• asymmetric synthesis
• nucleophilic addition
• hydrogenation

Trifluoromethylated amines, especially optically active ones, are very important synthetic building blocks in the design of bioactive products. Over the past decades, the development of highly efficient methods for asymmetric synthesis of Trifluoromethylated amines and their derivatives has attracted a continuing interest. A brief overview will give an insight into the asymmetric synthesis of trifluoromethylated amines and their derivatives from trifluoromethyl imines, nucleophilic trifluoromethylation tamed, fluorine-containing allylic esters, and by enzymatic catalysis.

• 出版日期2016
• 单位浙江中医药大学; 浙江大学