A degradable, bioactive, gelatinized alginate hydrogel to improve stem cell/growth factor delivery and facilitate healing after myocardial infarction

作者：Della Rocca Domenico G; Willenberg Bradley J; Ferreira Leonardo F; Wate Prateek S; Petersen John W; Handberg Eileen M; Zheng Tong; Steindler Dennis A; Terada Naohiro; Batich Christopher D; Byrne Barry J; Pepine Carl J^*

来源：Medical Hypotheses, 2012, 79(5): 673-677.

DOI：10.1016/j.mehy.2012.08.006

Despite remarkable effectiveness of reperfusion and drug therapies to reduce morbidity and mortality following myocardial infarction (MI), many patients have debilitating symptoms and impaired left ventricular (LV) function highlighting the need for improved post-MI therapies. A promising concept currently under investigation is intramyocardial injection of high-water content, polymeric biomaterial gels (e.g., hydrogels) to modulate myocardial scar formation and LV adverse remodeling. We propose a degradable, bioactive hydrogel that forms a unique microstructure of continuous, parallel capillary-like channels (Capgel). We hypothesize that the innovative architecture and composition of Capgel can serve as a platform for endogenous cell recruitment and drug/cell delivery, therefore facilitating myocardial repair after MI.

• 出版日期2012-11