A transmembrane inner nuclear membrane protein in the mitotic spindle

作者：Figueroa Ricardo; Gudise Santhosh; Larsson Veronica; Hallberg Einar^*

来源：Nucleus-Austin, 2010, 1(3): 249-253.

• inner nuclear membrane
• transmembrane proteins
• mitotic spindle
• spindle matrix
• mitosis
• cancer
• LINC complex
• centrosome
• dystonia

We have recently characterized a novel transmembrane protein of the inner nuclear membrane of mammalian cells. The protein has two very interesting features. First, despite being an integral membrane protein it is able to concentrate in the membranes colocalizing with the mitotic spindle in metaphase and anaphase. Hence, the protein was named Samp1, Spindle associated membrane protein 1. Secondly, it displays a functional connection to centrosomes. This article discusses various aspects of Samp1 in relation to possible cellular s).

• 出版日期2010-6