Automation in the High-throughput Selection of Random Combinatorial Libraries-Different Approaches for Select Applications

作者：Gloekler Joern; Schuetze Tatjana; Konthur Zoltan

来源：Molecules, 2010, 15(4): 2478-2490.

DOI：10.3390/molecules15042478

• phage display
• SELEX
• automation
• random combinatorial library
• in vitro evolution

Automation in combination with high throughput screening methods has revolutionised molecular biology in the last two decades. Today, many combinatorial libraries as well as several systems for automation are available. Depending on scope, budget and time, a different combination of library and experimental handling might be most effective. In this review we will discuss several concepts of combinatorial libraries and provide information as what to expect from these depending on the given context.

• 出版日期2010-4