An interactive website for analytical method comparison and bias estimation

作者：Bahar Burak^*; Tuncel Ayse F; Holmes Earle W; Holmes Daniel T

来源：Clinical Biochemistry, 2017, 50(18): 1025-1029.

DOI：10.1016/j.clinbiochem.2017.08.008

• Method comparison
• Clinical chemistry
• R programming
• Shiny
• Website

Objectives: Regulatory standards mandate laboratories to perform studies to ensure accuracy and reliability of their test results. Method comparison and bias estimation are important components of these studies.
Design & methods: We developed an interactive website for evaluating the relative performance of two analytical methods using R programming language tools. The website can be accessed at https://bahar.shinyapps.io/method_compare/.
Results: The site has an easy-to-use interface that allows both copy-pasting and manual entry of data. It also allows selection of a regression model and creation of regression and difference plots. Available regression models include Ordinary Least Squares, Weighted-Ordinary Least Squares, Deming, Weighted-Deming, Passing-Bablok and Passing-Bablok for large datasets. The server processes the data and generates downloadable reports in PDF or HTML format.
Conclusions: Our website provides clinical laboratories a practical way to assess the relative performance of two analytical methods.

• 出版日期2017-12