Action of Nicotine and Ovariectomy on Bone Regeneration After Tooth Extraction in Rats

作者：Ribeiro Machado Giscard Jose; Damasio Dias Sheila Monica; Bosco Alvaro Fancisco; Okamoto Tetuo; Bedran de Castro Joao Cesar; Menegati Dornelles Rita Cassia

来源：Journal of Oral and Maxillofacial Surgery, 2010, 68(11): 2675-2681.

DOI：10.1016/j.joms.2010.04.018

Purpose: The purpose of this study was to evaluate the effects of nicotine and ovariectomy on alveolar bone regeneration after exodontias in rats.
Materials and Methods: For 30 days, sham ovariectomized (OVX)/NaCl, sham OVX/nicotine, OVX/NaCl, and OVX/nicotine animals were given 2 daily injections of saline or hemisulfate of nicotine. After this period, exodontic procedures were carried out and treatment continued up to the time of euthanasia on clays 7 and 14 when the alveoli were removed for further analyses.
Results: The data confirmed that nicotine significantly delays the alveolar regeneration process after dental extraction in rats and showed that the association of nicotine with ovariectomy exacerbates these results.
Conclusion: These results indicate that nicotine potentiated the effect of estrogen deficiency on bone regeneration induced by ovariectomy.

• 出版日期2010-11