Atrophic gastritis and enlarged gastric folds diagnosed by double-contrast upper gastrointestinal barium X-ray radiography are useful to predict future gastric cancer development based on the 3-year prospective observation

作者：Yamamichi Nobutake^*; Hirano Chigaya; Ichinose Masao; Takahashi Yu; Minatsuki Chihiro; Matsuda Rie; Nakayama Chiemi; Shimamoto Takeshi; Kodashima Shinya; Ono Satoshi; Tsuji Yosuke; Niimi Keiko; Sakaguchi Yoshiki; Kataoka Yosuke; Saito Itaru; Asada Hirayama Itsuko; Takeuchi Chihiro; Yakabi Seiichi; Kaikimoto Hikaru; Matsumoto Yuta; Yamaguchi Daisuke; Kageyama Yahara Natsuko; Fujishiro Mitsuhiro; Wada Ryoichi; Mitsushima Toru; Koike Kazuhiko

来源：Gastric Cancer, 2016, 19(3): 1016-1022.

DOI：10.1007/s10120-015-0558-0

• Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR)
• Atrophic gastritis
• Enlarged gastric folds
• Gastric cancer
• Helicobacter pylori

Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is the standard gastric cancer screening method in Japan. Atrophic gastritis and enlarged gastric folds are considered the two major features of Helicobacter pylori-induced chronic gastritis, but the clinical meaning of evaluating them by UGI-XR has not been elucidated.
We analyzed healthy UGI-XR examinees without a history of gastrectomy, previous Helicobacter pylori eradication and usage of gastric acid suppressants.
Of the 6433 subjects, 1936 (30.1 %) had atrophic gastritis and 1253 (19.5 %) had enlarged gastric folds. During the 3-year prospective observational follow-up, gastric cancer developed in seven subjects, six of whom (85.7 %) had atrophic gastritis with H. pylori infection and five of whom (71.4 %) had enlarged gastric folds with H. pylori infection. The Kaplan-Meier method with log-rank testing revealed that both UGI-XR-based atrophic gastritis (p = 0.0011) and enlarged gastric folds (p = 0.0003) are significant predictors for future gastric cancer incidence.

• 出版日期2016-7