科研之友
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摘要
OBJECTIVES: The aim of this study was to evaluate the association of nutritional (folate, vitamin B-12) and genetic (MTHFR, MTR, MTRR, TCN) determinants of homocysteine metabolism and of superoxide dismutase with Crohn's disease (CD).
METHODS: One hundred forty patients with CD were compared with 248 matched healthy controls.
RESULTS: Plasma homocysteine levels were higher in CD patients than controls (11.8 vs 10.4 mu mol/L, P 0.0004). Vitamin B-12 and folate levels were lower in CD subjects compared to controls (207 vs 255 pmo/L, P = 0.0082, and 8.6 vs 11 nmol/L, P = 0036, respectively). Patients with a personal history of ileal resection, ileitis, or colectomy had significantly lower vitamin B-12 levels. In multivariate analysis, vitamin B-12 and MTHFR 677 TT carriers were the two significant independent factors of plasma homocysteine > 15 mu mol/L in CD patients (P = 0.0187 and 0.0048, respectively). The significant association between homocysteine and vitamin B-12 levels remained significant only in patients with the highest superoxide dismutase values (P < 0.0001). The MTRR AA genotype was a significant independent predictor of CD risk (odds ratio 3.7, 95% CI 1.218-11.649, P = 0.0213). The level of superoxide dismutase was significantly higher (P = 0.0143) and was correlated with Crohn's Disease Activity Index (CDAI) scores (P for trend = 0.0276) in patients carrying MTRR AA genotype.
CONCLUSIONS: Vitamin B-12 and MTHFR 677 TT genotype are the main determinants of hyperhomocysteinemia in CD patients. The association of MTRR 66A>G polymorphism with oxidant stress and disease activity provides rationale for screening vitamin deficiencies in these patients.
- 出版日期2008-2
