Allogeneic hematopoietic stem cell transplantation for refractory mycosis fungoides (MF) and Sezary syndrome (SS)

作者：Atilla Erden^*; Atilla Pinar Ataca; Bozdag Sinem Civriz; Yuksel Meltem Kurt; Toprak Selami Kocak; Topcuoglu Pervin; Akay Bengu Nisa; Sanli Hatice; Gurman Gunhan; Ozcan Muhit

来源：International Journal of Hematology, 2017, 106(3): 426-430.

DOI：10.1007/s12185-017-2245-x

• Mycosis fungoides
• Sezary syndrome
• Allogeneic hematopoietic stem cell transplantation

Cutaneous T cell lymphoma is a heterogeneous group of lymphoproliferative disorders with different clinical behavior and prognosis in which malignant T cells accumulate in the skin. In the relapsed/refractory stage, treatment strategy varies depending on clinical perspective. We retrospectively evaluated advanced stage relapse or refractory mycosis fungoides and Sezary syndrome patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) at our hospital. The overall response rate was 25%, while the disease progressed and relapsed after transplant in 38% of patients. Allo-HSCT may be a reasonable treatment option in the relapsed/refractory stage.

• 出版日期2017-9