A novel strategy to the synthesis of 4-anilinoquinazoline derivatives

作者：Wang, Zheng; Wang, Cuiling; Sun, Yanni; Zhang, Ning; Liu, Zhulan; Liu, Jianli^*

来源：Tetrahedron, 2014, 70(4): 906-913.

DOI：10.1016/j.tet.2013.12.028

• A novel strategy
• Synthesis
• 4-Anilinoquinazoline
• Derivatives

A novel approach to prepare 4-anilinoquinazoline derivatives based on the transformation of indoline-2,3-dione to formamidine was developed. The processes with this approach are simple, efficient, and environmentally friendly. The efficiency of this approach was evaluated by synthesizing 17 4-anilinoquinazolines and comparing the obtained yields with those achievable through conventional synthetic methods. It was the first time that compounds 8d, 8e, 8h, and 13b-f were synthesized. The characteristics of the IR and the UV spectra of these compounds and the effects of their substituents on the spectra were observed.

• 出版日期2014-1-28
• 单位西北大学