Angiography with a multifunctional line scanning ophthalmoscope

作者：Hammer Daniel X^*; Ferguson R Daniel; Patel Ankit H; Vazquez Vanessa; Husain Deeba

来源：Journal of Biomedical Optics, 2012, 17(2): 026008.

DOI：10.1117/1.JBO.17.2.026008

• ophthalmology
• retinal imaging
• angiography
• line scanning ophthalmoscopy
• retinal tracking
• photodynamic therapy
• fluorescein
• indocyanine green

A multifunctional line scanning ophthalmoscope (mLSO) was designed, constructed, and tested on human subjects. The mLSO could sequentially acquire wide-field, confocal, near-infrared reflectance, fluorescein angiography (FA), and indocyanine green angiography (ICGA) retinal images. The system also included a retinal tracker (RT) and a photodynamic therapy laser treatment port. The mLSO was tested in a pilot clinical study on human subjects with and without retinal disease. The instrument exhibited robust retinal tracking and high-contrast line scanning imaging. The FA and ICGA angiograms showed a similar appearance of hyper- and hypo-pigmented disease features and a nearly equivalent resolution of fine capillaries compared to a commercial flood-illumination fundus imager. An mLSO-based platform will enable researchers and clinicians to image human and animal eyes with a variety of modalities and deliver therapeutic beams from a single automated interface. This approach has the potential to improve patient comfort and reduce imaging session times, allowing clinicians to better diagnose, plan, and conduct patient procedures with improved outcomes.

• 出版日期2012-2