Brain perfusion CT compared with(15)O-H2O-PET in healthy subjects

作者：Gruner Julie Marie^*; Paamand Rune; Hojgaard Liselotte; Law Ian

来源：EJNMMI Research, 2011, 1(1): 28.

DOI：10.1186/2191-219X-1-28

• brain perfusion imaging
• PET
• oxygen radioisotopes
• perfusion CT
• healthy human subjects

Background: Regional cerebral blood flow [rCBF] measurements are valuable for identifying angiogenically active tumours, and perfusion computed tomography [CT] has been suggested for that purpose. This study aimed to validate rCBF measurements by perfusion CT with positron-emission tomography [PET] and(15)O-labelled water [O-15-H2O] in healthy subjects.
Methods: RCBF was measured twice in 12 healthy subjects with(15)O-H2O PET and once with perfusion CT performed over the basal ganglia. Matching rCBF values in regions of interest were compared.
Results: Measured with perfusion CT, rCBF was significantly and systematically overestimated. White matter rCBF values were 17.4 +/- 2.0 (mean +/- SD) mL min(-1) 100 g(-1) for PET and 21.8 +/- 3.4 mL min(-1) 100 g(-1) for perfusion CT. Grey matter rCBF values were 48.7 +/- 5.0 mL min(-1) 100 g(-1) for PET and 71.8 +/- 8.0 mL min(-1) 100 g(-1) for perfusion CT. The overestimation of grey matter rCBF could be reduced from 47% to 20% after normalization to white matter rCBF, but the difference was still significant.
Conclusion: RCBF measured with perfusion CT does contain perfusion information, but neither quantitative nor relative values can substitute rCBF measured by(15)O-H2O PET yet. This, however, does not necessarily preclude a useful role in patient management.

• 出版日期2011