Antifungal activity of statins against Aspergillus species

作者：Qiao, Jianjun; Kontoyiannis, Dimitrios P.; Wan, Zhe; Li, Ruoyu; Liu, Wei^*

来源：Medical Mycology, 2007, 45(7): 589-593.

DOI：10.1080/13693780701397673

• Aspergillus spp.
• statins
• antifungal susceptibility testing
• in vitro

The cholesterol-lowering agents known as statins have in vitro activities against human pathogenic fungi, such as Candida species, Cryptococcus neoformans, and Zygomycetes. Synergy between statins and azoles against these fungi has also been reported. We evaluated the in vitro activities of two statins, lovastatin and simvastatin, alone and in combination with azoles and amphotericin B, against clinical isolates of Aspergillus spp. A disk diffusion assay showed that both statins were active against Aspergillus spp. The minimal inhibitory concentration (MIC) ranges for lovastatin and simvastatin against Aspergillus spp. were 16 to >256 mu g/ml and 4 to >256 mu g/ml, respectively. Although both statins were fungicidal for A. fumigatus, the MICs were vastly higher than clinically achievable concentrations. The results of a combined agar dilution-Epsilometer test as well as a disk diffusion assay showed that neither statin had any effect on the in vitro activities of itraconazole, voriconazole, or amphotericin B against Aspergillus spp.

• 出版日期2007-11
• 单位北京大学