Depression-resolving and spirit-tranquilizing effects of different compatibility of flavonoids in Ziziphi Spinosae Semen and spectrum-efficient correlation analysis [酸枣仁黄酮部位不同配伍的解郁安神作用及谱-效相关性分析]

作者：Song W; Tang S A; Cao B Y; Fu J W; Qiao W^*

来源：Chinese Traditional and Herbal Drugs, 2018, 49(5): 1123-1131.

DOI：10.7501/j.issn.0253-2670.2018.05.021

• 6′′′-feruloylspinosin
• 6′′′-p-hydroxybenzoylspinosin
• Flavonoids
• Glucosylvitexin
• Spectrum-efficient correlation
• Spinosin
• Vicenin-II
• Ziziphi Spinosae Semen

Objective: To establish the HPLC fingerprints of different compatibility of flavonoids in Ziziphi Spinosae Semen (ZSS) so as to establish spectrum-efficient correlation between HPLC fingerprints and the effects of depression-resolving and spirit-tranquilizing. Methods: Spearman analysis, grey relational analysis, and multiple regression analysis were used to correlate the peak area of the characteristic peaks of each component in the HPLC fingerprint with the behavior indexes of depressive and insomnia mice. Results: There were five chemical compositions strongly related with efficacy of flavonoids in ZSS, including vicenin-II, glucosylvitexin, spinosin, 6′′′-feruloylspinosin, and 6′′′-p-hydroxybenzoylspinosin. Conclusion: The effective components of flavonoids in ZSS with depression-resolving and spirit- tranquilizing effects can be inferred by spectrum-efficient correlation analysis, which can provide the basis for the screening and quality control of effective components of ZSS.

• 出版日期2018
• 单位天津医科大学