A Highly Reusable Rhodium Catalyst-Organic Framework for the Intramolecular Cycloisomerization of 1,6-Enynes

作者：Corkum Elizabeth G; Hass Michael J; Sullivan Andrew D; Bergens Steven H^*

来源：Organic Letters, 2011, 13(13): 3522-3525.

DOI：10.1021/ol201333s

The intramolecular cycloisomerization of 1,6-enynes in 95-99% ee is reported using an immobilized Rh catalyst-organic framework synthesized from alternating ring-opening metathesis polymerization (altROMP) assembly. The framework was reused up to seven times, and it was used in high turnover number (TON) batch reactions. The catalyst provided the highest TONs to date (up to 890) for the cycloisomerizations, with catalyst loadings ranging from 0.2 to 0.06 mol %.

• 出版日期2011-7-1