Addition of N-H bonds to iridium: Synthesis and characterization of N-Ir-H complexes and the observation that an iridium N-bonded indole ring becomes activated for Michael addition to alkynes

作者：Ladipo Folami T; Merola Joseph S^*

来源：Polyhedron, 2015, 90: 131-138.

DOI：10.1016/j.poly.2015.02.002

• N-H activation
• Oxidative addition
• Indole
• Iridium
• Michael addition

The thermal reaction between the electron-rich iridium complex, [IrCOD(PMe3)(3)]Cl, 1a, and pyrrolic or anilinic N-H bonds results in the oxidative addition of the N-H bond and the formation of an amido iridium hydride complex, HIr(amido)(Cl)(PMe3)(3) with loss of COD. The only isomer formed in this reaction has a meridional arrangement of PMe3 ligands, with H trans to Cl and the amido group trans to PMe3. The reaction products of 1a with pyrrole, indole and 3-methyl indole were fully characterized included by single crystal X-ray diffraction. Attachment of the pyrrolic ring nitrogen to the iridium results in an electron rich ring system that is activated and adds to alkynes in a Michael addition reaction under mild conditions without a catalyst.

• 出版日期2015-4-18
• 单位美国弗吉尼亚理工大学(Virginia Tech)