Development of Ethanolic Nano Vesicles of Tenoxicam, Investigation of Transdermal Penetration Efficiency and Histological Safety Comparison with Common Penetration Enhancers

作者：Negi Lalit Mohan; Fatma Sharmeen; Talegaonkar Sushama; Chauhan Meenakshi^*

来源：Nanoscience and Nanotechnology Letters, 2013, 5(5): 600-605.

DOI：10.1166/nnl.2013.1593

• Ethosome
• Tenoxicam
• Ethanol
• Transdermal

The aim of this work is to develop a safe and effective transdermal formulation for potent anti-inflammatory agent, tenoxicann. The drug suffers from poor transdermal permeation and hence ethosomal vesicles were optimized in attempt to provide a deep penetrating nano-formulation without causing undue damage to the skin. The effects of the components of ethosome i.e., ethanol and lecithin were evaluated in terms of size, entrapment, zeta-potential and permeation. TEV-4 formulation with 30% ethanol and 1% lecithin was found to be optimal choice for the transdermal permeation of tenoxicam. A confocal laser scanning microscopy (CLSM) study with dual fluorescent probes showed remarkable capability of optimized ethosomes to deliver both hydrophilic and hydrophobic moieties to the deeper tissue layers. The present investigation also demonstrated the relative safety of developed formulation over some common penetration enhancers via microscopic evaluation.

• 出版日期2013-5