Anorectal malformation and associated end-stage renal disease: Management from newborn to adult life

作者：Giuliani Stefano^*; Midrio Paola; De Filippo Roger E; Vidal Enrico; Castagnetti Marco; Zanon Giovanni Franco; Gamba Pier Giorgio

来源：Journal of Pediatric Surgery, 2013, 48(3): 635-641.

DOI：10.1016/j.jpedsurg.2012.10.073

• Anorectal malformation
• Genito-urinary anomalies
• Chronic renal failure
• Peritoneal dialysis
• Kidney transplantation
• Children

Background/Objective: Renal failure remains one of the most significant causes of morbidity in patients with anorectal malformations (ARM). In the modern era, an increasing number of children born with ARM and genito-urinary (GU) anomalies reach adulthood and require continued multidisciplinary care for the rest of their life. The aim of this study is to present our institutional experience in the management of pediatric chronic renal failure related to severe GU anomalies and anorectal malformations. %26lt;br%26gt;Methods and Results: Three hundred twenty-one patients with ARM have been followed at our institution since 1987. Six patients developed end-stage renal disease (ESRD) and received a kidney transplant at different ages. One patient is currently followed for mild, progressive chronic renal failure. These seven cases are reported along with a broad discussion concerning etiology of renal failure, neonatal surgical management, pediatric dialysis, urologic issues, and kidney transplantation. %26lt;br%26gt;Conclusion: Complex GU anomalies associated with ARM require a long-term approach by specialized pediatric and adult clinicians to optimize the care of this selected population of patients.

• 出版日期2013-3