Association between glycemic indices and beta cell function in patients with newly diagnosed type 2 diabetes

作者：Fang, Fu Sheng; Cheng, Xiao Ling; Gong, Yan Ping; Wang, Liang Chen; Li, Lin; Li, Jian; Tian, Hui; Li, Chun Lin^*

来源：Current Medical Research and Opinion, 2014, 30(8): 1437-1440.

DOI：10.1185/03007995.2014.918030

• Glycated hemoglobin
• Glycemic variability
• Type 2 diabetes

Objective: To identify the relationship between glycemic indices and 13 cell function in patients with newly diagnosed type 2 diabetes.
Methods: The cross-sectional analysis included 61 patients with newly diagnosed type 2 diabetes who received continuous glucose monitoring (CGM) for 72 hours. The association between p cell function and glycemic indices including A1C and glycemic variability was investigated.
Results: A1C (r=-0.405, p=0.001) and standard deviation of blood glucose (SDBG, r=0.274, p=0.032) were significantly correlated to HOMA-beta cell HBCI), whereas mean amplitude of glycemic excursions (MAGE, r=-0.210, p=0.104) was not informative. After multiple confounders adjustments, A1C (3=-7.35, p<0.001), MAGE (beta=-4.64, p=0.040), and SDBG (beta=12.3, p=0.012) were associated with HBCI.
Conclusion: A1C and glycemic variability were both associated with beta cell function in patients with newly diagnosed type 2 diabetes. The main limitations of the present study are the cross-sectional design in nature and the limited sample size.

• 出版日期2014-8
• 单位中国人民解放军总医院