Process Optimization, Physical Properties, and Environmental Stability of an alpha-Tocopherol Nanocapsule Preparation Using Complex Coacervation Method and Full Factorial Design

作者：Sharifi Faezeh; Hadizadeh Farzin^*; Sadeghi Fatemeh; Mosavian M T Hamed; Zarei Camellia

来源：Chemical Engineering Communications, 2016, 203(1): 64-74.

DOI：10.1080/00986445.2014.973941

• alpha-Tocopherol
• Complex coacervation
• Full factorial design
• Nanocapsules
• Stability

alpha-Tocopherol (alpha-Toc) has valuable biological activity, but its activity is limited when exposed to environmental factors. Nanocapsules can be used to overcome this problem. Using nanocapsules in the range of 100-200nm is more beneficial. A 2(4) full factorial design was carried out to optimize the size of nanocapsules using the complex coacervation method. The four factors were the amount of the wall material, the ratio of core material to wall material, the pH of the solution, and the speed of the homogenizer. The smallest nanocapsules (176 nm) were obtained at a wall content (gelatine and pectin) of 0.8 mg, a percentage of core material (alpha-Toc) to wall material of 20%, a pH = 4.5, and a homogenizer speed of 12,000 rpm. The encapsulation efficiency was 90.6 +/- 1.1%, and the encapsulation yield was 83.4 +/- 1.6%. Assessment of the stability of alpha-Toc after 1 month showed that encapsulation could improve its stability in the presence of three influential factors: humidity, light, and temperature.

• 出版日期2016