A Bio-Acoustic Levitational (BAL) Assembly Method for Engineering of Multilayered, 3D Brain-Like Constructs, Using Human Embryonic Stem Cell Derived Neuro-Progenitors

作者:Bouyer Charlene; Chen Pu; Gueven Sinan; Demirtas Tugrul Tolga; Nieland Thomas J F; Padilla Frederic*; Demirci Utkan
来源:Advanced Materials, 2016, 28(1): 161-+.
DOI:10.1002/adma.201503916

摘要

A bio-acoustic levitational assembly method for engineering of multilayered, 3D brainlike constructs is presented. Acoustic radiation forces are used to levitate neuro-progenitors derived from human embryonic stem cells in 3D multilayered fibrin tissue constructs. The neuro-progenitor cells are subsequently differentiated in neural cells, resulting in a 3D neuronal construct with inter and intralayer neurite elongations.

  • 出版日期2016-1-6