One-pot synthesis of dihydrobenzisoxazoles from hydroxylamines, acetylenedicarboxylates, and arynes via in situ generation of nitrones

作者：Li, Pan; Wu, Chunrui; Zhao, Jingjing; Li, Yang; Xue, Weichao; Shi, Feng^*

来源：Canadian Journal of Chemistry, 2013, 91(1): 43-50.

DOI：10.1139/cjc-2012-0199

• nitrone
• aryne
• dipolar cycloaddition
• reactive intermediate
• dihydrobenzisoxazole

Aryne [3 + 2] cycloaddition with nitrones generated in situ from the addition of hydroxylamines to acetylenedicarboxylates affords moderate to good yields of dihydrobenzisoxazoles. This reaction extends the current scope of aryne cycloaddition to include in situ generated nitrones and produces functionalized dihydrobenzisoxazoles with a quaternary center.

• 出版日期2013-1
• 单位河南大学