Acupuncture and moxibustion reduces neuronal edema in Alzheimer's disease rats

作者：Zhou, Hua; Sun, Guojie^*; Kong, Lihong; Du, Yanjun; Shen, Feng; Wang, Shuju; Chen, Bangguo; Zeng, Xiaoling

来源：Neural Regeneration Research, 2014, 9(9): 968-972.

DOI：10.4103/1673-5374.133148

• nerve regeneration
• brain injury
• acupuncture and moxibustion
• pretreatment
• Alzheimer's disease
• axin
• beta-catenin
• NSFC grant
• neural regeneration

To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer's disease, we established a rat model of Alzheimer's disease and measured axin and beta-catenin expression in the hippocampus. Rats were pretreated with moxibustion or electroacupuncture, or both, at Baihui (GV20) and Shenshu (BL23). Axin expression was lower, beta-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. Our results suggest that the mechanism underlying the neuroprotective effect of acupuncture and moxibustion in Alzheimer's disease is associated with axin and beta-catenin expression in the Wnt signal transduction pathway.

• 出版日期2014-5
• 单位湖北中医药大学