Anti-inflammatory cytokines in endometriosis

作者：Zhou, Wen-Jie; Yang, Hui-Li; Shao, Jun; Mei, Jie; Chang, Kai-Kai; Zhu, Rui; Li, Ming-Qing^*

来源：Cellular and Molecular Life Sciences, 2019, 76(11): 2111-2132.

DOI：10.1007/s00018-019-03056-x

• Endometriosis
• Cytokine
• Anti-inflammatory
• IL-10
• TGF-
• Endometrial stromal cells
• Macrophage
• T cells
• NK cells

Although the pathogenesis of endometriosis is notfully understood, it is often considered to be an inflammatory disease. An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (e.g., interleukin-4 and -10, and transforming growth factor-1) occurs in women with endometriosis, including in serum, peritoneal fluid and ectopic lesions. These anti-inflammatory cytokines also have indispensable roles in the progression of endometriosis, including by promoting survival, growth, invasion, differentiation, angiogenesis, and immune escape of the endometriotic lesions. In this review, we provide an overview of the expression, origin, function and regulation of anti-inflammatory cytokines in endometriosis, with brief discussion and perspectives on their future clinical implications in the diagnosis and therapy of the disease.

• 出版日期2019-6
• 单位同济大学; 复旦大学; 南京大学; 上海市计划生育科学研究所