Anti-Mullerian Hormone: genetic and environmental effects

作者：Shahrokhi Seyedeh Zahra; Kazerouni Faranak^*; Ghaffari Firouzeh

来源：Clinica Chimica Acta, 2018, 476: 123-129.

DOI：10.1016/j.cca.2017.11.027

• Anti-Mullerian hormone
• Ovarian reserve
• Genetic factors
• MTHFR polymorphism
• Environmental factors
• Vitamin D deficiency

Anti-Mullerian hormone (AMH) is a homodimeric glycoprotein produced by granulosa cells of growing ovarian follicles. AMH appears to have an inhibitory effect on both primordial follicle recruitment and responsiveness of growing follicles to follicle-stimulating hormone (FSH). This hormone is considered to be a reliable marker of ovarian reserve; therefore, it is crucial to determine which factors influence AMH levels for prognostic and diagnostic purposes. In this review we intend to discuss the effect of genetic and environmental factors which may lead to AMH interindividual variability.

• 出版日期2018-1