Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in an area of high endemicity in Republic of Korea

作者：No Jin Sun; Kim Won keun; Kim Jeong Ah; Lee Seung Ho; Lee Sook Young; Kim Ji Hye; Kho Jeong Hoon; Lee Daesang; Song Dong Hyun; Gu Se Hun; Jeong Seong Tae; Kim Heung Chul; Klein Terry A; Song Jin Won^*

来源：Microbiology and Immunology, 2016, 60(4): 268-271.

DOI：10.1111/1348-0421.12370

• epidemiology
• Hantaan virus
• virus-host interaction

Hantaan virus (HTNV), of the family Bunyaviridae, causes hemorrhagic fever with renal syndrome (HFRS) in humans. Although the majority of epidemiologic studies have found that rodents are seropositive for hantavirus-specific immunoglobulin, the discovery of hantavirus RNA in seronegative hosts has led to an investigation of the presence of HTNV RNA in rodents captured in HFRS endemic areas. HTNV RNA was detected in seven (3.8%) of 186 anti-HTNV IgG seronegative rodents in Republic of Korea (ROK) during 2013-2014. RT-qPCR for HTNV RNA revealed dynamic virus-host interactions of HTNV in areas of high endemicity, providing important insights into the epidemiology of hantaviruses.

• 出版日期2016-4