Anaplastic carcinoma of the pancreas: Case report and literature review of reported cases in Japan

作者：Hoshimoto Sojun^*; Matsui Junichi; Miyata Ryohei; Takigawa Yutaka; Miyauchi Jun

来源：World Journal of Gastroenterology, 2016, 22(38): 8631-8637.

DOI：10.3748/wjg.v22.i38.8631

• Anaplastic carcinoma
• Pancreatic cancer
• Pleomorphic type
• Prognosis
• Undifferentiated carcinoma

We report a case of a 64-year-old woman with anaplastic carcinoma of the pancreas (ACP) with cyst formation and review 60 ACP cases reported in Japan. In 20% of cases, laboratory tests revealed severe anemia (hemoglobin level < 10.0 g/ dL) and elevated leucocyte counts (> 12000/ mm(3)), which were likely attributable to rapid tumor growth, intratumoral hemorrhage, and necrosis. Elevated serum CA19-9 levels were observed in 55% of cases. Cyst-like structures were observed on imaging in 47% of cases, and this finding appears to reflect subsequent cystic degeneration in the lesion. Macroscopically, hemorrhagic necrosis was observed in 77% of cases, and cyst formation was observed in 33% of cases. ACP should be considered when diagnosing pancreatic tumors with a cyst-like appearance, especially in the presence of severe anemia, elevated leucocyte counts, or elevated serum CA19-9 levels.

• 出版日期2016-10-14