Differential Adaptive Responses of Staphylococcus aureus to In Vitro Selection with Different Antimicrobial Peptides

作者：Shireen Tahsina; Singh Madhuri; Das Tiyasa; Mukhopadhyay Kasturi^*

来源：Antimicrobial Agents and Chemotherapy, 2013, 57(10): 5134-5137.

DOI：10.1128/AAC.00780-13

We subjected Staphylococcus aureus ATCC 29213 to serial passage in the presence of subinhibitory concentrations of magainin 2 and gramicidin D for several hundred generations. We obtained S. aureus strains with induced resistance to magainin 2 (strain 55MG) and gramicidin D (strain 55GR) that showed different phenotypic changes in membrane properties. Both exhibited a change in membrane phospholipid content and an increase in membrane rigidity, while an alteration in net charge compared to that of the control occurred only in the case of 55MG.

• 出版日期2013-10